These terms are best regarded as synonymous with rate-controlling step. However, other meanings that have been given to them should be mentioned, as it is necessary to be aware of them in order to avoid confusion:
Sometimes the term rate-determining is used as a special case of rate-controlling, being assigned only to an initial slow step which is followed by rapid steps. Such a step imposes an upper limit on the rate, and has also been called rate-limiting.
In view of the considerable danger of confusion when special meanings are applied to rate-determining and rate-limiting, it is recommended that they be regarded as synonymous, with the meaning explained under the entry rate-controlling step. See Michaelis-Menten kinetics. IUPAC CHEMICAL KINETICS (1991).
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