binding site definition

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binding site definition

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A specific region (or atom) in a molecular entity that is capable of entering into a stabilizing interaction with another molecular entity . An example of such an interaction is that of an active site in an enzyme with its substrate. Typical forms of interaction are by hydrogen bonding, coordination, and ion pair formation.

Two binding sites in different molecular entities are said to be complementary if their interaction is stabilizing.

binding site definition

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