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Structure-based design is a drug design strategy based on the 3D structure of the target obtained by X-ray or NMR.
Structure-property correlations (SPC)Structure-property correlations refers to all statistical mathematical methods used to correlate any structural property to any other property (intrinsic, chemical or biological), using statistical regression and pattern recognition techniques.
SystemicSystemic means relating to or affecting the whole body.
TeratogenA teratogen is a substance that produces a malformation in a foetus.
Three-dimensional Quantitative Structure-Activity Relationship (3D-QSAR)
A three-dimensional quantitative structure-activity relationship is the analysis of the quantitative relationship between the biological activity of a set of compounds and their spatial properties using statistical methods.
Topliss treeA Topliss tree is an operational scheme for analog design.
Transition-state analogA transition-state analog is a compound that mimics the transition state of a substrate bound to an enzyme.
XenobioticA xenobiotic is a compound foreign to an organism (xenos [greek] = foreign).
Return to home page for Glossary of Terms Used in Medicinal Chemistry .
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