A measure of the capability of a solute for hydrophobic (lipophilic) interaction based on the partition coefficient P for distribution of the solute between octan-1-ol and water. The most general way of applying P in correlation analysis, QSAR, etc. is as log P, but the behaviour of substituted benzene derivatives may be quantified by a substituent constant scale, , which is defined in a way analogous to the Hammett scale. There are various scales, depending on the substrate series used as reference. HANSCH and LEO (1979).
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